Scientist/Sr. Scientist, Oligo Biology – In Vitro
Employment Information
Report this job
Job expired or something wrong with this job?
Job Description
Scientist/Sr. Scientist managing in vitro screening and optimizing oligonucleotides for Korsana Biosciences. Collaborating with internal teams and external partners to enhance therapeutic candidates.
Responsibilities:
- Design molecular and cellular biology experiments in close collaboration with internal bioinformatics and chemistry teams to support robust in vitro and in vivo screening campaigns.
- Manage external CROs, including experimental design, priority setting, technical oversight, data review, timeline management, and proactive troubleshooting to ensure high-quality, timely project execution.
- Design and optimize siRNAs, ASOs, PMOs, and other novel nucleotide modalities to enhance therapeutic profiles.
- Generate and interpret structure-activity relationships (SAR) to guide lead optimization and candidate selection.
- Maintain thorough technical documentation using Electronic Lab Notebooks (ELNs) and effectively communicate experimental strategies, results, and recommendations to multidisciplinary scientific audiences.
- Actively evaluate emerging technologies and scientific literature to identify innovative approaches that enhance oligonucleotide potency, extrahepatic delivery, durability, and safety.
Requirements:
- Ph.D. in biology, pharmaceutical sciences, or related discipline with 0-6 years of relevant industry experience, OR M.S. with 2-8 years of industry experience in oligonucleotide therapeutic development.
- Deep understanding of siRNA and ASO design principles, cellular mechanisms of action, and chemical modification strategies.
- Familiarity with state-of-the-art oligonucleotide delivery technologies, including GalNAc conjugates, lipid conjugates, peptide/antibody-oligonucleotide conjugates (AOCs), or other targeted delivery methods.
- Hands-on experience with mammalian cell culture, diverse transfection methodologies.
Benefits:
- Eligible for target annual bonus
- Equity-based compensation
- Participation in the company’s benefit programs
Similar Jobs
Senior Bioinformatics Scientist
Senior Bioinformatics Scientist at Veracyte driving next-generation MRD test development. Collaborating with cross-functional teams for robust clinical diagnostics delivery.
Scientist/Sr. Scientist, Oligo Chemistry
Scientist/Sr. Scientist in Oligonucleotide Chemistry leading oligonucleotide discovery programs. Collaborate with cross-functional teams for therapeutic oligonucleotides development.
PK Scientist
Senior PK Scientist providing clinical pharmacology expertise in protocol development and analysis for Phase I–IV clinical trials. Collaborating with cross-functional teams in regulated environments.
Health Scientist I
Health Scientist I supporting CDC public health evaluation initiatives remotely from Atlanta. Engaging in evaluation planning, data analysis, and technical assistance activities.
Health Scientist II
Health Scientist II supporting public health evaluation initiatives for CDC. Conducting evaluation planning, data analysis, and technical assistance.
Biocompatibility Scientist
Scientist Biocompatibility at Johnson & Johnson evaluating biological safety of medical devices. Collaborating with cross-functional teams to ensure product compliance with regulations and standards.
Health Scientist II
Health Scientist providing scientific and technical support for health-related research and initiatives, analyzing data and collaborating with teams to meet program objectives while ensuring compliance.
Health Scientist I
Health Scientist providing scientific and technical support for health-related research programs. Analyzing data, collaborating with teams, and preparing documentation for federal compliance responsibilities.
Field Applications Scientist – NGS Bioinformatics
Field Bioinformatics Application Scientist providing advanced technical support in NGS bioinformatics for the clinical sequencing division. Collaborating with teams to resolve complex issues and enhance customer experience.
Senior Scientist, LPI Modeling – Beam Smoothing
Senior Scientist focusing on laser system requirements and the LPI modeling for clean fusion energy solutions. Collaborating across teams to support experimentation and theoretical contributions in plasma physics.
Senior Medical Affairs Scientist, Amyloidosis
Senior Medical Affairs Scientist specializing in medical affairs within ATTR-CM at Pfizer. Focusing on external relationships and scientific expertise for Tafamidis with clinical experts.
Variant Scientist
Variant Scientist working with Clinical Teams on patient molecular reports for clinical utility. Involved in classifying genetic variants and summarizing test results.
Field Applications Scientist
Field Applications Scientist at Standard BioTools conducting customer training and applications support for CyTOF Mass Cytometry platforms. Engaging in technical sales support and troubleshooting user issues in a flexible environment.
Therapeutic Medical Scientist
Therapeutic Medical Scientist providing scientific expertise in cardiovascular therapeutic area for Cytokinetics. Engaging with healthcare providers and contributing to medical strategies addressing cardiac diseases.
No more related jobs available.