Senior Bioinformatics Scientist
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Job Description
Senior Bioinformatics Scientist developing algorithms and scalable pipelines for Natera’s cfDNA cancer diagnostics. Analyzing genomic data to advance early cancer detection.
Responsibilities:
- Innovate, design, develop, and validate advanced algorithms and statistical models to extract actionable insights from large-scale genomic datasets for early cancer detection
- Co-architect, implement, and deploy automated analysis workflows for clinical diagnostics, including variant calling, fusion detection, and automated quality control
- Contribute to code reviews, maintain technical documentation, and drive continuous optimization of core computational infrastructure
- Analyze complex multi-omic data using high-performance internal pipelines
- Collaborate with wet-lab scientists and statisticians to meet critical research milestones
Requirements:
- Ph.D. in Bioinformatics, Computer Science, Statistics, Cancer Biology, or a related quantitative field
- 0–3 years of professional or postgraduate experience in bioinformatics or computational biology
- Excellent communication skills with ability to present complex computational findings to diverse cross-functional stakeholders
- Deep expertise in high-throughput DNA sequencing (NGS) analysis, including sequence alignment, mapping, and clinical-grade variant calling
- Proven track record of developing state-of-the-art, high-impact bioinformatics methodologies
- Advanced knowledge of data structures, algorithm design, and computational complexity analysis
- High proficiency in Python and its scientific ecosystem (NumPy, Pandas, Scikit-learn)
- Experience with workflow orchestration languages; WDL preferred
- Experience with cloud-based distributed computing environments, specifically AWS
- Familiarity with analytical techniques and biomarkers in cancer biology
- Working knowledge of public genomic databases such as TCGA, COSMIC, or OncoKB
- Proficiency in Linux environments, including command-line tools and shell scripting
Benefits:
- Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
- Free testing for employees and their immediate families
- Fertility care benefits
- Pregnancy and baby bonding leave
- 401k benefits
- Commuter benefits
- Employee referral program
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