Principal AI Engineer
Employment Information
Report this job
Job expired or something wrong with this job?
Job Description
Principal AI Engineer building Natera’s Vector Store GenAI Platform for clinical document intelligence. Setting retrieval architecture and shipping production AI systems for oncology and healthcare workflows.
Responsibilities:
- Own platform architecture and hands-on delivery for the Vector Store GenAI Platform, including search and retrieval, document processing and chunking, ingestion pipelines, and APIs serving downstream AI workflows
- Set technical direction for hybrid search and retrieval quality
- Evaluate embedding models and retrieval approaches through implementations, POCs, and benchmarks
- Advance document parsing and chunking for accurate, structured, and faceted retrieval
- Build stable, reproducible retrieval for agent and re-extraction workloads, including durable content identifiers, context assembly, versioned indices, and quality or confidence signals
- Strengthen document classification and ingestion visibility across historical and ongoing data flows
- Improve retrieval quality through deduplication, clinical concept normalization, and promising retrieval methods
- Integrate LLM capabilities into production systems with attention to performance, scalability, cost, observability, and safe operation in a regulated environment
- Partner with clinical AI, engineering, product, and SME stakeholders to prioritize workstreams, define success metrics, and sequence roadmap investments
- Provide principal-level technical leadership through architecture decisions, design reviews, documentation, mentoring influence, and pragmatic tradeoffs
Requirements:
- Bachelor’s or Master’s degree in Computer Science, Engineering, or a related technical field
- 10+ years of software engineering experience, including substantial ownership of production systems at scale
- 5+ years building and shipping AI/ML-powered applications in production
- Deep hands-on experience in retrieval-augmented systems, vector search, and document-centric AI pipelines, including indexing, retrieval quality, evaluation, and integration with downstream LLM or agent systems
- Demonstrated track record as a principal or equivalent individual contributor
- Strong hands-on expertise in Python and modern software engineering practices, including testing, code review, workflow orchestration, and agile delivery in large existing codebases
- Experience designing and operating AI systems in cloud environments; AWS strongly preferred
- Experience with CI/CD, observability, and production support
- Ability to work independently as an architecture-plus-build individual contributor and influence without direct authority
- Strong communication across technical and non-technical audiences
- Experience with clinical or structured healthcare documents and document-centric search or RAG systems is strongly preferred
- Experience in healthcare, life sciences, or other regulated industries is strongly preferred
- Experience designing retrieval interfaces used by agents or multi-step LLM workflows is a plus
Benefits:
- Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
- Free testing for Natera employees and their immediate families
- Fertility care benefits
- Pregnancy and baby bonding leave
- 401k benefits
- Commuter benefits
- Employee referral program
Similar Jobs
AI Architect
AI Architect designing secure, scalable AI and ML solutions for a federal healthcare modernization program. Leading enterprise architecture, cloud integration, MLOps, and responsible AI practices.
AI Architect I
Agentic AI Architect designing scalable, reusable architectures for RealPage’s production AI agents. Translating workflows into reliable orchestration, integration, evaluation, and observability patterns.
AI Developer IV
Senior Agentic AI Platform Engineer building reusable orchestration, runtime, and reliability infrastructure. Enabling RealPage product teams to develop, release, evaluate, and operate production AI agents.
Legal & Compliance Lead – AI
Kovo's first legal and compliance hire building AI-enabled financial products for underserved consumers. Owning regulatory strategy, product launches, automation, and partner relationships.
Senior AI Developer, Technology Engineer
Senior AI Developer Technology Engineer accelerating generative AI training and inference on NVIDIA platforms. Optimizing algorithms, architectures, frameworks, and low-level software with developers and researchers.
Staff Applied AI Engineer
Staff Applied AI Engineer building production LLM agents for Future’s Health Coach product. Developing reliable AI features for personalized sleep, nutrition, and fitness guidance.
Senior AI Engineer
Senior AI Engineer building and operating production LLM workflows for Jeeves' stablecoin-native banking platform. Owning AI systems end to end across design, deployment, evaluation, and monitoring.
Software Engineer – AI Evaluation
Software Engineer building AI evaluation systems for Board Intelligence’s board-governance platform. Automating quality measurement across full-stack tools, data pipelines and AI products.
Senior Full Stack Software Engineer, AI-Driven Platform
Senior Full Stack Engineer building scalable AI biomanufacturing software for pharmaceutical and biotech companies. Developing APIs, interfaces, and platform features that improve manufacturing efficiency and reduce waste.
Senior Customer AI Engineer
Senior Customer AI Engineer guiding customers from proof-of-concept to production on Nebius’s AI cloud platform. Optimizing reliable, scalable, and cost-efficient AI workloads.
Senior AI Engineer, AI FDE
Senior AI Engineer building and deploying production GenAI applications for Databricks customers. Advising customers and shaping AI product roadmaps through Databricks professional services.
Machine Learning/AI Engineer
Senior AI Engineer building production GenAI and agentic workflows for Ambush’s financial-services clients. Developing Python/FastAPI, SQL, RAG, and cloud-based AI systems.
Senior iOS Engineer, AI First
Senior iOS Engineer building AI-assisted seller and buyer apps for OPENLANE’s digital used-vehicle marketplace. Leading SwiftUI/UIKit architecture, testing, releases, and cross-platform mobile collaboration.
Senior Software Engineer – AI-Augmented Development
Senior Software Engineer building AI-augmented hyperautomation and workflow-management software at German IT provider DATAGROUP. Developing secure fullstack applications, APIs, CI/CD pipelines, and test strategies.
AI Engineer
AI Engineer owning production LLM workflows for Jeeves’ stablecoin-native banking platform. Building reliable AI systems for finance automation, monitoring, and regulated financial decisions.
AI Engineer
AI Engineer building end-to-end LLM workflows for Jeeves’ stablecoin-native banking platform. Shipping reliable finance automation with evaluation, monitoring, and backend integration.
AI Engineer
AI Engineer owning production LLM workflows for Jeeves’s stablecoin-native banking platform. Building reliable, evaluated AI systems for enterprise finance operations.
AI Engineer
AI Engineer owning production LLM workflows for Jeeves’ stablecoin-native banking platform. Building, evaluating, and monitoring AI systems for finance automation.
AI Developer
AI builders developing real projects in recorded OpenCode sessions for Mercor’s AI research partner. Using provided open-weight and Gemini models on flexible, remote tasks.
Builder, Developer – AI Coding Sessions
AI builders develop real projects in recorded OpenCode sessions using provided open-weight and Gemini models. Mercor supports AI research into how people build with coding assistants.