Scientist, Cell Therapy
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Job Description
Scientist in Cell Therapy advancing CAR T programs by managing assays and collaborating across project teams. Involved in study design, execution, analysis, and mentorship in a research environment.
Responsibilities:
- Own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization
- Partner with project teams to enable data-driven decisions that advance programs from discovery toward translation
- Help shape study plans, and ensure timely delivery of milestones across functions
- Design and run in vitro studies for CAR T candidates; design constructs and characterize engineered cell therapies; develop, execute, and optimize functional assays
- Analyze data, generate figures, and prepare reports and slide decks, present results and propose next experiment steps
- Ensure adherence to required training and maintain accurate, complete experimental records
- Align with Pharmacology & Toxicology, CMC, translational science and clinical teams to advance project
- Clear scientific writing and presentation, mentor colleagues and foster a productive, well-organized lab environment
- Track record of trouble shooting models, optimizing protocols, and meeting timelines in a dynamic environment
Requirements:
- PhD in immunology, cell biology, or related field; or MS with 4+ years demonstrated impact in cell therapy discovery
- Proficient in human primary cell isolation, culture, activation, and maintenance
- Prepare lentiviral vectors and perform transduction; optimize MOI to maximize transduction efficiency; assess vector copy number and integration characteristics; conduct electroporation-based gene edits
- Proficient in panel design, compensation, and gating
- Functional assays: target killing (luciferase/impedance), cytokines, proliferation/persistence, serial-kill or rechallenge assays; antigen density titration and specificity testing
- PCR/qPCR, plasmid prep; amplicon NGS prep for edit verification and transgene integrity
- Proficiency with ELN, FlowJo, Snapgene, GraphPad; understanding of assay acceptance criteria and basic statistics
- Practice BSL 2 biosafety, uphold animal ethics (IACUC), maintain awareness of research GxP, and ensure data integrity
Benefits:
- Health insurance
- Professional development
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